Eye wrinkles, nasolabial folds or crow’s feet are expression lines that appear as a consequence of natural aging.
De Felipe Dermatology Clinic, has studied carefully how to eliminate wrinkles on the face. Our specialists in anti-aging medicine will help you to achieve a young and natural appearance with different treatments as well as the use of botulinum toxin in London.

What is Botulinum Toxin?

Botulinum toxin is a relatively small protein that penetrates nerve endings, those that stimulate muscles or sweating glands. Muscle contraction is smoothened in those places where botulinum toxin is injected and dynamic wrinkles and lines are reduced. Its correct name is botulinum neurotoxin type A (BNTA).

BNTA in its pure form is wrapped in several different proteins, among which are mostly hemagglutinins or HA. These are made inside some bacteria in laboratories. Each pharmaceutical company has its own way of obtaining BNTA together with these HA. Therefore, each botulinum toxin has its own composition and is formed by a slightly different molecular composition and weight. This explains why each laboratory gives a different name to these compounds. De Felipe Dermatology Clinic experts have been working in the advisory board of some of these pharmaceutical companies and delivering training and performing research for many years.

Types of botulinum toxin type A

There are different types of botulinum neurotoxin type A. Despite the fact that they all contain in its core the same molecule, their final composition differs from one another. These changes have an impact in several aspects that we must take into account.


The complex formed by this type of neurotoxin is 900 kd in size, of which 150 is the neurotoxin itself (BNTA) and the rest are protein compounds. It should be stored in between 2-8ºC and can be stored for two years.


They are formed by a 500 kd protein complex that has no therapeutic function but reduces its ability to migrate. It should be kept between 2-8ºC and can be stored for 2 years.


No load of complexing proteins. Significantly reduces the risk of production of neutralizing antibodies. It does not require cold storage but can stay at room temperature for three years.


With a size of 150 kd, this type of toxin is injected no more than every 3 months.

Botulinum toxin treatment London

Wrinkle treatment in the Dermatology Clinic in London is performed on an outpatient basis, it does not require prior anesthesia and recovery is immediate.

What does the treatment consist of?

Wrinkle treatment in London with botulinum toxin consists of introducing a minimal amount of the product into the skin with a very fine needle, very superficially, in the area where there are facial expression wrinkles such as the crow’s feet, the glabella lines or the forehead.

Botulinum toxin is stored in a small sterile glass container. The Doctor dilutes it with a little physiological saline solution making it ready for injection. A small 30g needle is injected to minimize damage into several points of the skin, under which the muscles to be relaxed are located.

If the patient finds the procedure painful, a little bit of topical anesthesia for 15 or 20 minutes can be applied, but that’s rarely required for a procedure that otherwise lasts one or two minutes.

Procedure duration

15 minutes

Type of anesthesia

Does not require

Clinical result

To be seen, from 1 to 2 weeks.

Recovery time


Results last for

From 3 to 6 months

How to reduce wrinkles on the face?

Discover those areas of your face where we can apply botulinum toxin to reduce wrinkles, prevent sagging and enjoy a youthful and nice appearance.


London wrinkle reduction treatment price

The price of treating wrinkles in London is:

Price per session

  • 1 area


  • 2 areas


  • 3 areas


  • Full face



Wrinkles before and after

No change is observed Immediately after the treatment.
Botulinum toxin does not start to work until the fifth day after the injection. However, the patient can resume his work and social life without any delay. A small bruise might rarely appear in the treated area but disappears shortly after. Expression are reduced and the result is a natural and relaxed face.

Patients ask

Patients looking for information on how to remove wrinkles in our London clinic:

No. The full effect is seen between 5 and 15 days later.
Botulinum toxin is completely eliminated from the nerve endings in 6 months. That means that by 3 months after the injection, 40-50% of the effect of the drug is still observed. Compared with other medication, botulinum toxin is a very long-lasting drug and takes a long time to be completely absorbed.
Botulinum toxin does not migrate but diffuses into a small area around its point of injection. It diffuses approximately one centimetre around the injection point so it cannot reach areas of the skin or body far away from its injection point.
Botulinum toxin is one of the safest drugs in medicine. In fact, botulinum toxin has been injected for decades and millions of treatments have been performed. It is estimated that in the United States alone, 5 million treatments are performed each year, of which well over half are performed to reduce facial wrinkles and excessive sweating.
The procedure is minimally painful and very well tolerated.
It is recommended not to do physical exercise for 4 hours after treatment or go to swimming pools or saunas, but this is just a recommendation based on the pharmaceutical label. It doesn’t seem these activities will modify its effect.
Patients with wounds or active skin infections in the area to be treated, chronic illnesses, feverish states and/or general malaise should not undergo the treatment for wrinkles.
Some patients might experience a difficulty in raising the upper eyelid, but this effect is always completely reversible. Some of these patients had already difficulty in elevating the upper eyelid before the treatment but it is enhanced just after the treatment with botulinum toxin. Some patients might experience diplopia or double vision as a consequence of a diffusion of the product into eye muscles. Again, this effect is transitory and wanes away quickly. Some patients respond poorer than others which has made experts think of the possibility of resistance to the treatment. But usually after increasing the dose, these patients also respond.